![]() Immunohistochemistry demonstrated that Sm-p80/ Sm-p80 ortholog proteins are expressed in different life cycle stages of the three major human species of schistosomes studied. haematobium challenge trials and these are associated with the prophylactic efficacy of Sm-p80 vaccine. A balanced Th1 (IFN-γ, TNF-α, IL-2, and IL-12) and Th2 (IL-4, IgG1) type of responses were observed following vaccination in both S. haematobium-hamster infection/challenge model. DNA prime/protein boost (1 + 1 dose administered on a single day) resulted in 26.95% reduction in worm burden in S. Immunization with Sm-p80 vaccine reduced worm burden by 46.75% against S. We also elucidated the expression of Sm-p80 and Sm-p80 ortholog proteins in different developmental stages of S. ![]() haematobium challenge infections in rodent models. In this study, we evaluated the cross-species protective efficacy of Sm-p80 vaccine against S. mansoni challenge infections in mice and baboons. Schistosoma mansoni large subunit of calpain ( Sm-p80)-based vaccine formulations have shown remarkable efficacy in protecting against S. ![]() Despite large-scale schistosomiasis control efforts, clear limitations such as possible emergence of drug resistance and reinfection rates highlight the need for an effective schistosomiasis vaccine. Schistosomiasis remains a major global health problem. Molehin, Adebayo J Sennoune, Souad R Zhang, Weidong Rojo, Juan U Siddiqui, Arif J Herrera, Karlie A Johnson, Laura Sudduth, Justin May, Jordan Siddiqui, Afzal A Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80/ Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium. Ada juga yang menilainya sebagai suatu sistem " peradaban yang menyeluruh ". Ada yang melihatnya sebagai suatu " masyarakat sipil ". Sebagai sebuah alat untuk memahami kehidupan, Islam sering dianggap sebagai sesuatu yang lebih dari sekadar agama. Jadi keberadaan pemerintah wajib menurut hukum syari'ah' dan tidak ada alasan untuk meninggalkannya. Sesuatu yang tanpa dasar akan runtuh dan Suatu dasar tanpa penjaga akan hilang. Imam Al Ghazali mentamsilkan agama ibarat pondasi dan sulthan (kekuasaan politik) sebagai penjaganya. ![]() Al Mawardi menyebut fungsi pemerintahan adalah untuk mengganti fungsi kenabian guna memelihara agama dan mengatur urusan dunia. Abstract Islam adalah agama paripurna dimana dalam pandangan mereka sistem politik dan pemerintahan adalah bagian dari ajaran agama. So it is evident from the concept of Maqashid al-Shariah, it is very clear that the correlation between economic politics, Islamic politics has the same goals and principles for the purpose of creating "prosperity". The relationship between Maqashid Shari'a and mashlahah is very closely related, since the purpose of the maqashid of shari'a itself is to achieve mashlahah (welfare). In the context of Dharuriyah, in particular "guarding the state," Islam obliges Muslims to have a state that governs them with laws that Allah has revealed and develops Islamic treatises to mankind, in other words having a state in charge of its affairs with Islam which it believes to be an aqeedah and life system. With such personality, will be able to meet the criteria of ideal leaders, namely leaders who are able to create peace and prosperity of the world. Even Ibn Khaldun provides a prerequisite for a leader who is so strict as to require a leader to have a philosophical personality. Therefore, the obligation to appoint political leaders is determined by the agreement of the Muslims (ijma '), based on the consideration of revelation (religion). Sunni political thinkers have argued that leadership issues are a worldly matter. ![]() Ibn Khaldun's core idea of political and state concepts is an attempt to create a religious state order that guarantees the benefit of mankind. Ibn Khaldun's political thought of the state is in fact a reflection of the moral concept as shown in Islamic social history, especially during the reign of the Prophet. There are also those who regard it as a "whole civilization" system. As a tool for understanding life, Islam is often regarded as something more than a religion. So the existence of the government is obligatory according to Shariah law 'and there is no reason to leave it. Something without foundation will collapse and An unattended base will be lost. Imam Al Ghazali mentamsilkan religion as the foundation and sulthan (political power) as a guard. Al Mawardi called the function of government is to replace the function of prophethood in order to maintain the religion and govern the affairs of the world. Islam is a plenary religion where in their view the political system and government are part of the religious teachings. ![]()
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